• Scientific Subcommittee on Molecular Biology, 1993
• Awards Selection Committee, 1990-1993
• Public Relations Committee, 1990-1992
Cancer and Leukemia Group B:
• Core member of Immunology and Genetics Committee, 1987 to 1995
• Principal Investigator of Protocols 8761, 8762 and 9265
Editorial Advisory Boards
Experimental Hematology, 2002 - 2006
Blood, 2000 - 2006
Former: Leukemia and Lymphoma; Gene Therapy; Molecular Diagnosis; Human Molecular Genetics
BOOKS AND ARTICLES
Westbrook, CA. Ask an Oncologist: Honest Answers to Difficult Questions about Cancer. February 2012, Litle Plum Press.
Westbrook, CA. To Your Health! The Beer Doctor on Good Beer, Good Times, and the Finer Things in Life. July, 2014. Little Plum Press.
SELECTED PUBLICATIONS OUT OF 105, full list available on request
Westbrook, CA, Groopman, JE, Golde, DW. Hairy-cell leukemia: disease pattern and prognosis. Cancer 54:500-6, 1984
Le Beau, M, Westbrook, CA, Diaz, MO, Rowley, JD. Evidence for two distinct c-src loci on human chromosomes 1 and 20. Nature 312:70-71, 1984.
Gasson, JC, Golde, DW, Kaufman, SE, Westbrook, CA, Hewick, RM, Kaufman, RJ, Wong, GG, Temple, PA, Leary AC, Brown, EL, Orr,EC, and Clark, SC. Molecular characterization and expression of the gene encoding human erythroid potentiating activity. Nature 315:768-771, 1985.
Le Beau, MM, Westbrook, CA, Diaz, MO, Rowley, JD, and Oren, M. Translocation of the p53 gene in t(15;17) in acute promyelocytic leukemia. Nature 316:826-828, 1985.
Le Beau, MM, Westbrook, CA, Diaz, MO, and Rowley, JD. C-src is consistently conserved in the deletion (20q) in myeloid disorders. Proc. Natl. Acad. Sci. 82:6692-6696, 1985.
Westbrook, CA, Le Beau, MM, Diaz, MO, Groffen, J, and Rowley, JD. Chromosomal localization and characterization of c-abl in the t(6;9) of acute nonlymphocytic leukemia. Proc. Natl. Acad. Sci. 82:8742-8746, 1985.
Le Beau, MM, Westbrook, CA, Diaz, MO, Larson, RA, Rowley, JD, Gasson, JC, Golde, DW, and Sherr, CJ. Evidence for the involvement of GM-CSF and FMS in the deletion (5q-) in myeloid disorders. Science 231:984-987, 1986.
Westbrook, CA, Rubin, CM, Le Beau, MM, Kaminer, L, Diaz, MO, Smith, SD, and Rowley, JD. The chromosomal breakpoint in a translocation 7,9 in a human T-cell leukemia cell line is proximal to c-abl. Proc. Natl. Acad. Sci. USA 84:251-255, 1987.
Ratain, MJ, Golomb, HM, Bardawil, RG, Vardiman, JW, Westbrook, CA, Kaminer, LS, Lembersky, BC, Bitter, MA and Daly, K. Durability of responses to interferon alfa-2b in advanced hairy cell leukemia. Blood 69:872-877, 1987.
Bernards A, Rubin C, Westbrook CA, Paskind M, Baltimore D. The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia. Molecular and Cellular Biology 7:3231-3236, 1987.
Rubin, CM, Carrino, JJ, Dickler, MN, Leibowitz, D, Smith, SD, and Westbrook, CA. Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia. Proc. Natl. Acad. Sci. USA 85:2795-2799, 1988.
Westbrook, CA. The ABL Oncogene in Human Leukemias. Blood Reviews 2:1-8, 1988.
Rubin, CM, Blazar, BR, Hooberman, AL, Dickler, MN, Miller, BA, and Westbrook, CA. A deletion/insertion polymorphism in the human BCR gene on chromosome 22. Nucl. Acids Res. 16:8741, 1988.
Hooberman, AL, Rubin, CM, Barton, KP, and Westbrook, CA. Detection of the Philadelphia chromosome in acute lymphoblastic leukemia by pulsed field gel electrophoresis. Blood 74:1101-11097, 1989.
Hooberman, AL, Carrino, JJ, Leibowitz, D, Rowley, JD, Le Beau, MM, Arlin, ZA, Westbrook, CA. “Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome positive acute lymphoblastic leukemia”. Proc. Natl. Acad. Sci. 86:4259-4263, 1989.
Michelassi, R, Erroi, F, Angriman, I, Westbrook, CA. Chromosome 5 allele loss in human gastric, ampillary, and pancreatic carcinomas. Ital. J. Surg. Sciences 19:341-344, 1989.
Tkachuk, DC, Westbrook, CA, Andreeff, M, Donlon, RA, Clearly, ML, Homge, M, Redner, A, Gray, J, Pinkel, D. Detection of BCR-ABL fusion in chronic myelogenous leukemia by two-color fluorescence in situ hybridization. Science 250:559-562, 1990.
Westbrook, CA. “Effect on physician-scientists of the low funding rate of NIH grant applications”. Letter to the editor, New Engl. J. Med. 323:1283, 1990.
Becker, MA, Heidler, SA, Bell, GI, Seino, S, Le Beau, MM, Westbrook, CA, Neuman, W, Shapiro, LJ, Mohandas, TK, Roesssler, BJ, Pallela, TD. Cloning of cDNAs for human phosphorbosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes. Genomics 8:555-561, 1990.
Wasylyshyn, MI, Neuman, WL, Angriman, I, Snyder, LA, Montag, AG, Westbrook, CA, Michelassi, F. Evidence for a new tumor-suppressor gene involved in gastrointestinal malignancies. Surgery 110:265-269, 1991.
Westbrook, C., Neuman, W, Hewitt, J, Le Beau, M, Kidd, K, Williamson, R. Report of the First International Workshop of Human Chromosome 5. Genomics 10:1105-1109, 1991.
Westbrook, CA, Neuman, WL, McPherson, J, Camper, S, Wasmuth, J, Plaetke, R and Williamson, R. Report of the second international workshop for human chromosome 5. Cytogenet Cell Genet 61:225-242, 1992.
Calabrese, G, Palka, G, Westbrook, CA and Sheer D. Complex translocation involving Ph chromosome in a patient with typical chronic myelogenous leukemia. Cytogenetics Cell Genetics 63 (1):52-55, 1992.
Le Beau, MM, Espinosa III, R, Neuman, WL, Stock, W, Roulston, D, Larson, RA, Keinanen, M and Westbrook, CA. Cytogenetic and molecular delineation of the smallest commonly deleted region of chromosome 5 in myeloid leukemias. Proc. Natl. Acad. Sci. USA 90:5484-5488, 1993..
Yaremko, ML, Wasylyshyn, ML, Paulus, KL, Michelassi, F, Westbrook, CA. Deletion mapping reveals two regions of chromosome 8 allele loss in colorectal carcinomas. Genes, Chromosomes and Cancer 10:1-6, 1994.
Kelemen, PR, Yaremko, ML, Kim, AH, Montag, AH, Michelassi, F, Westbrook, CA. Loss of heterozygosity in 8p is associated with microinvasion in colorectal carcinoma. Genes, Chromosomnes and Cancer 11:195-198, 1994.
Stock, W, Thirman, MJ, Diaz, MO, Rowley, JD, Bloomfield, CD, Wurster-Hill, D, Sobol, RE, Dodge, RK, Larson, RA, Westbrook, CA. Detection of MLL gene rearrangements in adult ALL. A Cancer and Leukemia Group B Study. Leukemia 8:1918-1922, 1994.
Westbrook, CA, Chmura, SJ, Arenas, RB, Kim, S-Y, Otto, G. Human APC gene expression in rodent colonic epithelium in vivousing liposomal gene delivery. Human Molecular Genetics 3:2005-2010, 1994.
Yamaoka, LH, Westbrook, CA, Speer, MC, Cilchrist, JM, Jabs, EW, Schweins, EG, Stajich, JM, Gaskell, PC, Roses, AD, Pericak-Vance, MA. Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1 locus between D5S178 and IL9. Neuromuscular Disorder 4:471-475, 1994.
Larson, RA, Dodge, RK, Burns, PC, Lee, EJ, Davey, FR, Sobol, RE, Frankel, S, Hooberman, AL, Westbrook, CA, George, SL, Bloomfield, CD, Schiffer, CA. A five drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 8811. Blood 85:2025-2037, 1995.
Takanishi, DM, Jr, Angriman, I, Yaremko, ML, Montag, AG, Westbrook, CA, Michelassi, F. Chromosome 17p allelic loss in colorectal carcinoma: Clinical significance. Arch Surg 130(6):585-588; discussion, 588-589, 1995.
Yaremko, ML, Recant, WT, Westbrook, CA. Loss of heterozygosity from the short arm of chromosome 8 is an early event in breast cancers. Genes, Chromosomes and Cancer 13:186-191, 1995.
Speer, MC, Gilchrist, JM, Chutkow, JG, McMichael, R, Westbrook, CA, Stajich, JM, Jorgenson, EM, Gaskell, PC, Rosi, BL, Ramesar, R, Vance JM, Yamaoka, LH, Pericak-Vance, MA. Evidence for locus heterogeneity in autosomal dominat limb-girdle muscular dystrophy. Am. J. Hum. Genet. 57:1371-1376, 1995.
Horrigan, SK, Westbrook, CA, Anne, H, Kim, AH,, Banerjee, M, Stock, W, Larson, R. Polymerase chain reaction-based diagnosis of del(5q) in aculte myeloid leukemia and myelodysplastic syndrome identified a minimal deletion interval. Blood 88: 2665-2670, 1996.
Yaremko, ML, Kutza, C, Lyzak, J, Mick, R, Recant, WM, Westbrook, CA. Loss of heterozygosity from the short arm of chromosome 8 is associated with invasive behavior in breast cancer. Genes, chromsomes & cancer 16:189-195, 1996.
Stock, W., Westbrook, CA, Peterson, B, Arthur, DC, Szatrowski, TP, Silver, RT, Sher, DA, Wu, D, Le Beau, MM, Schiffer, CA, Bloomfield, CD. Value of molecular monitoring during the treatment of chronic myelogenous leukemia. J. Clin. Onc. 15:26-36, 1997.
Takanishi, DM, Kim, SY, Kelemen, PR, Yaremko, ML, Kim, AH, Ramesar, JE, Horrigan, SK, Montag, A, Michelassi, F, Westbrook, CA. Chromosome 8 Losses in Colorectal Carcinoma: Localization and Correlation with Invasive Disease. Molecular Diagnosis 2:1-8, 1997.
Westbrook, C.A. Molecular subsets and prognostic factors in acute lymphoblastic leukemia. Leukemia 11 (Suppl. 4): S8-S12, 1997.
Bruno, E, Horrigan, SK, Van Den Berg, D, Rozler, E, Fitting, PR, Moss, ST, Westbrook, CA, Hoffman, R. The Smad5 gene is involved in the intracellular signaling pathways which mediate the inhibitory effects of transforming growth factor-b on human hematopoiesis. Blood. 91(6):1917-1923, 1998.
Kim, S.Y., Horrigan, S.K., Altenhofen, J.L., Arbieva, Z.H., Hoffman, R., Westbrook, C.A. Modification of Bacterial Artificial Clones using Cre Recombinase: Introduction of selectable markers for expression in eukaryotic cells. Genome Research. 8:404-412, 1998.
Goldberg, PA, Madden, MV, Harosopos, C, Felix, R, Westbrook, C, Ramesar, R. In a resource-poor country, mutation identification has the potential to reduce the cost of family management for hereditary non-polyposis colorectal cancer. Dis. Colon Rectum. 41:1250-3, 1998.
Arbieva ZH, Banerjee K, Kim SY, Maniatis V, Horrigan SK, Westbrook CA. High resolution physical map and transcription identification at a prostate cancer deletion interval on chromosome 8, band p22. Genome Research 10:244-257, 2000.
Ramesar RS, Madden MV, Felix R, Harocopos CJ, Westbrook CA, Jones G, Cruse JP, Goldberg PA. Molecular Genetics improves the management of hereditary nonpolyposis colorectal cancer. S. African Med. Jour. 90:709-14, 2000.
Horrigan SK, Arbieva ZH, Xie X, Kravarusic J, Fulton N, Le T, Westbrook CA. Delineation of a minimal interval and identification of 9 candidates for a tumor suppressor gene in malignant myeloid disorders on 5q31. Blood, 95:2372-2377, 2000.
Hauser MA, Horrigan SK, Salmikangas P, Torian UM, Viles KD, Dancel R ,Tim R, , Taivainen U, Bartoloni L, Gilchrist JM, Stajich JM, Gaskell PC, Gilbert JR, Vance JM, Pericak-Vance MA, Carpen O, Westbrook CA, Speer MC. Myotillin is mutated in limb girdle muscular dystrophy 1A. Human Molec. Genet. 9:2141-2147, 2000.
Westbrook CA, Hsu W-T, Chyna B, Litvak D, Raza A, Horrigan SJ. Cytogeneic and molecular features of chromosome 5 deletions in myelodysplasia . British J. of Haematology 110:847-855, 2000.
Xie H, Hu Z, Chyna B, Horrigan S, Westbrook CA. Human Mortalin (HSPA9): Candidate for the Myleoid Leukemia Tumor Suppressor Gene on 5q31. Leukemia 14:2128-2134, 2000.
Hu ZB, Gomes I, Horrigan SK, Kravarusic J, Mar BG, Arbieva Z, Chyna B, Fulton N, Edassery S, Raza A, Westbrook CA. A nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31. Oncogene 20:6946-6954, 2001.
Szatrowski TP, Dodge RK, Reynolds C, Westbrook CA, Frankel SR, Sklar J, Stewart C, Hurd D, Kolitz JE, Velez-Garcia E, Bloomfield CD, Schiffer CA, Larson RA. Lineage-Specific treatment of adult acute lymphoblastic leukemia in first remission: CALGB Study 9311. Cancer 97:1471-1480, 2003
Stitziel NO, Mar, BG, Liang J, Westbrook CA, Membrane-Associated and Secreted Genes in Breast Cancer. Cancer Research, Cancer Res. 2004 64: 8682-8687..
SELECTED CHAPTERS, out of 16
Gasson JC, Chen ISY, Westbrook CA, and Golde DW. Lymphokines and Hematopoiesis in Normal and Neoplastic Hematopoiesis, Alan R. Liss, Inc., New York.
Golomb HM, Ratain M, Westbrook C, and Daly K. “The Treatment of Hairy Cell Leukemia “in: Leukemia: Recent Advances in Biology and Treatment. (Eds. R.P. Gale and D.W. Golde). Alan R. Liss, Inc., N.Y. pp. 115-724, 1985.
Westbrook CA, Golomb HM. "The treatment of B-cell malignancy" in Recent Advances in Clinical Immunology, vol. 4, R.A. Thompson, editor, 1987.
Westbrook CA. "Analysis of the Philadelphia Chromosome by Pulsed Field Gel Electrophoresis " In: Molecular Approaches to the Study and Treatment of Philadelphia Chromosome Positive Leukemia. A. Deisseroth, editor, in press.
Hooberman AL, Westbrook CA. "Molecular Methods to Detect the Philadelphia Chromosome," Clinics in Laboratory Medicine 10: 839-855, 1990.
Westbrook CA and Le Beau MM. "Deletions of 5q and Myeloid Leukemias" In: The Causes and Consequences of Chromosomal Aberrations. Ilan R. Kirsch, MD, Editor. CRC Press, USA, 1993.
Yaremko ML, Wasylyshyn ML, Michelassi F, Westbrook CA. Oncogenes, suppressor genes, and allele losses in colon cancer. Advances in Surgery Vol. 26, pp. 323-332, 1993, Mosby Year Book, Chicago.
Westbrook, CA. “The Molecular Basis of Neoplasia” in: Hematology: Basic Principles and Practice, 4th ed. R. Hoffman, ed. Elsevier / Churchill Livingston, Philadelphia PA, 2005. pp 941-954.
PROFESSIONAL MONOGRAPHS AND ABSTRACTS
FULL LIST AVAILABLE ON REQUEST
OTHER PROFESSIONAL ACTIVITIES
RESEARCH GRANTS AWARDED: 41, full list available on request
RESEARCH SUPERVISION : 6 PhD students, full list available on request
FELLOWSHIP ADVISOR: Supervised 12 recipients, full list available on request
GRADUATE TEACHING: at Univ. of Illinois, and Univ. of Chicago, full list available on request
TELEVISION AND PUBLIC APPEARANCES
WVIA Television, Wilkes-Barre, PA, September 25, 2012 "Ask The Doctor"
WNIT Television, South Bend, IN, March 2007 “Ask an Expert”
WFWA Television, Fort Wayne, IN, June 2007 “PBS Healthline”
WFWA Television, Fort Wayne, IN, May 2008 “PBS Healthline”
WFWA Television, Fort Wayne, IN Dec 2008 “PBS Healthline”
"A Bottle a Day Keeps the Doctor Away," opening speaker at the Master Brewers' Association of the Americas, Oct 8, 2015.
"The Abnormal Blood Count: When do I Consult?” Cancer Update for Primary Care Physicians, Goshen Center for Cancer Care, Oct 19, 2007
“Principles of Cancer Treatment,” Cancer Rehabilitation Workshop, Goshen General Hospital, March 29, 2007
“Genetic Testing for Cancer Predisposition”. Chicago Bar Associations’ Alliance for Women, March 27, 2001, Chicago, Illinois.
“Diagnostic challenges in the Family Cancer Clinic: new genes, new diseases”. Genetic Task Force of Illinois, December 8, 2000.
“Genetic Counseling and DNA Testing for Adult Familial Cancers”. University of Illinois, Medical Grand Rounds, 10/14/ 1999
Carol A. Westbrook. Methods and Compositions for the Detection of Chromosomal Aberrations. U.S. Patent No. 6,025,126, Feb 15, 2000.
Joe W. Gray, Daniel Pinkel, Douglas Tkachuk, Carol A. Westbrook. “Chromosome Specific Staining to Detect Genetic Rearrangements.” US Patent Serial No. 444,669 Dec 1989 / continuation of US Serial No. 937,793/ continuation of US Serial No. 819,314 / continuation of US Serial No. 382,094.
E Brown, D Golde, R Hewick, SC Clark, JC Gasson, Carol A. Westbrook. "Vectors containing a gene for a protein having erythroid-potentiative activity and recombinant DNA methods for producing said protein" US Patent Application Serial No. 656,590, filed Oct. 1, 1984.
Medical Volunteer at the Care and Concern Free Health Clinic, Pittston, PA, 2013-2015
Liason to Care House, a non-profit residence for cancer patients, Goshen IN, August 2007 to 2009
Board of Directors, American Theater Company, Chicago Illinois, 2002-2004
Lincoln Park High School Drama Parents’ Group, founder 2000, participant 1996-2004
Pines Township, Precinct 2, Vice Precinct Captain, 2001 to 2002.
Visiting teacher, Illinois Math and Science Academy, Aurora, Illinois, Intercession mini-course, January 2003.